Management of symptomatic uterine fibroids requires a personalized approach drawing from a broad spectrum of Therapeutic Options, dictated by symptom severity, fibroid location, and fertility preservation goals. At the least invasive end are non-hormonal medications like NSAIDs and tranexamic acid, used to manage pain and heavy bleeding, alongside hormonal agents such as oral contraceptives and progestin-releasing IUDs for symptom control.

The middle tier encompasses the uterus-sparing, minimally invasive procedures (UFE, RFA, MRgFUS) and myomectomy, the surgical removal of fibroids while leaving the uterus intact, often performed robotically or laparoscopically to minimize incision size and recovery time. At the most definitive end of the spectrum is hysterectomy, the removal of the entire uterus, which is chosen for women with severe, persistent symptoms who have completed childbearing and wish for a permanent cure, reflecting the diversity of solutions available in the space.

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